BRD-K28120222_Prestw-550_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K28120222_Prestw-550_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KDM3A lysine (K)-specific demethylase 3A
LHFPL2 lipoma HMGIC fusion partner-like 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
NELL2 NEL-like 2 (chicken)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RORA RAR-related orphan receptor A
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
DUSP4 dual specificity phosphatase 4
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXA5 homeobox A5
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS5 regulator of G-protein signaling 5
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRPX sushi-repeat containing protein, X-linked
TWIST1 twist family bHLH transcription factor 1
VIM vimentin