BRD-K28115298_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K28115298_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADA adenosine deaminase
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA6 annexin A6
AOX1 aldehyde oxidase 1
AREG amphiregulin
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASPH aspartate beta-hydroxylase
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C8ORF4 chromosome 8 open reading frame 4
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL6 chemokine (C-X-C motif) ligand 6
CYB5A cytochrome b5 type A (microsomal)
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBLN5 fibulin 5
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
FNBP1L formin binding protein 1-like
FOXO3 forkhead box O3
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
H3F3B H3 histone, family 3B (H3.3B)
HEBP1 heme binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
INSR insulin receptor
ISLR immunoglobulin superfamily containing leucine-rich repeat
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LMCD1 LIM and cysteine-rich domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC16A leucine rich repeat containing 16A
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKSL1 MARCKS-like 1
MFAP2 microfibrillar-associated protein 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MSN moesin
MSX1 msh homeobox 1
MT1X metallothionein 1X
MVP major vault protein
MYO1B myosin IB
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDLIM1 PDZ and LIM domain 1
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAC8 placenta-specific 8
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLS1 plastin 1
PROCR protein C receptor, endothelial
RAB29 RAB29, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A4 solute carrier family 16, member 4
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
STOM stomatin
STON1 stonin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TMEM135 transmembrane protein 135
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TREM1 triggering receptor expressed on myeloid cells 1
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WISP2 WNT1 inducible signaling pathway protein 2
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATF5 activating transcription factor 5
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CST3 cystatin C
CXCL11 chemokine (C-X-C motif) ligand 11
CYB561 cytochrome b561
DOCK10 dedicator of cytokinesis 10
DST dystonin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTZ1 glutathione S-transferase zeta 1
ICAM3 intercellular adhesion molecule 3
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
ING3 inhibitor of growth family, member 3
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MICALL1 MICAL-like 1
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MRPS35 mitochondrial ribosomal protein S35
NAAA N-acylethanolamine acid amidase
NKX3-1 NK3 homeobox 1
ODC1 ornithine decarboxylase 1
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RNF6 ring finger protein (C3H2C3 type) 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SPAG7 sperm associated antigen 7
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TOR1A torsin family 1, member A (torsin A)
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein