BRD-K27737647_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K27737647_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
BTN3A2 butyrophilin, subfamily 3, member A2
CD59 CD59 molecule, complement regulatory protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC3 chloride intracellular channel 3
CLIC4 chloride intracellular channel 4
CLU clusterin
CXCL5 chemokine (C-X-C motif) ligand 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO3 forkhead box O3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SQLE squalene epoxidase
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CLDN10 claudin 10
COL6A3 collagen, type VI, alpha 3
DPYSL3 dihydropyrimidinase-like 3
EPHA3 EPH receptor A3
FAIM Fas apoptotic inhibitory molecule
HRSP12 heat-responsive protein 12
IGFBP5 insulin-like growth factor binding protein 5
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAPK13 mitogen-activated protein kinase 13
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
NID2 nidogen 2 (osteonidogen)
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAEP progestagen-associated endometrial protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PLBD1 phospholipase B domain containing 1
PMM2 phosphomannomutase 2
PTGIS prostaglandin I2 (prostacyclin) synthase
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12