BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

25 genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KIAA0101 KIAA0101
MYRF myelin regulatory factor
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
F3 coagulation factor III (thromboplastin, tissue factor)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
NFIB nuclear factor I/B
PDGFD platelet derived growth factor D
RAP1GAP RAP1 GTPase activating protein
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
THBS1 thrombospondin 1
TP53 tumor protein p53