BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AIM2 absent in melanoma 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CA12 carbonic anhydrase XII
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CP ceruloplasmin (ferroxidase)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
FAM3C family with sequence similarity 3, member C
FKBP11 FK506 binding protein 11, 19 kDa
GSTA4 glutathione S-transferase alpha 4
GUSBP11 glucuronidase, beta pseudogene 11
HOPX HOP homeobox
IDO1 indoleamine 2,3-dioxygenase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL32 interleukin 32
JCHAIN joining chain of multimeric IgA and IgM
LPCAT1 lysophosphatidylcholine acyltransferase 1
MSX1 msh homeobox 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEB nebulin
NEFL neurofilament, light polypeptide
NT5DC2 5'-nucleotidase domain containing 2
POU2AF1 POU class 2 associating factor 1
PRF1 perforin 1 (pore forming protein)
PTCH1 patched 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPB surfactant protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SNX7 sorting nexin 7
SPON2 spondin 2, extracellular matrix protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AREG amphiregulin
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CEP170 centrosomal protein 170kDa
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM107A family with sequence similarity 107, member A
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLIPR1 GLI pathogenesis-related 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MIR22HG MIR22 host gene
NANS N-acetylneuraminic acid synthase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIP prolactin-induced protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SGK1 serum/glucocorticoid regulated kinase 1
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble