BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
BLVRB biliverdin reductase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CARS cysteinyl-tRNA synthetase
COL4A5 collagen, type IV, alpha 5
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FADS1 fatty acid desaturase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KRT16 keratin 16, type I
KRT6B keratin 6B, type II
MMP1 matrix metallopeptidase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PI3 peptidase inhibitor 3, skin-derived
S100A9 S100 calcium binding protein A9
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TCTA T-cell leukemia translocation altered
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CAB39 calcium binding protein 39
CCL21 chemokine (C-C motif) ligand 21
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DLC1 DLC1 Rho GTPase activating protein
DPYSL3 dihydropyrimidinase-like 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
KDSR 3-ketodihydrosphingosine reductase
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPD1 LY6/PLAUR domain containing 1
MAB21L2 mab-21-like 2 (C. elegans)
MGP matrix Gla protein
MYH11 myosin, heavy chain 11, smooth muscle
MYL9 myosin, light chain 9, regulatory
NMI N-myc (and STAT) interactor
PROM1 prominin 1
PTMA prothymosin, alpha
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SULF1 sulfatase 1
THBS1 thrombospondin 1
TSPAN8 tetraspanin 8