BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGA aspartylglucosaminidase
ANXA10 annexin A10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BCHE butyrylcholinesterase
BLVRB biliverdin reductase B
C1QB complement component 1, q subcomponent, B chain
CARS cysteinyl-tRNA synthetase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CD86 CD86 molecule
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRELD2 cysteine-rich with EGF-like domains 2
CTH cystathionine gamma-lyase
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT3 DNA-damage-inducible transcript 3
DIO1 deiodinase, iodothyronine, type I
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF1 eukaryotic translation initiation factor 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EXT1 exostosin glycosyltransferase 1
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GFAP glial fibrillary acidic protein
GJA1 gap junction protein, alpha 1, 43kDa
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IFT57 intraflagellar transport 57
IGKV4-1 immunoglobulin kappa variable 4-1
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
MARS methionyl-tRNA synthetase
MEST mesoderm specific transcript
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
SARS seryl-tRNA synthetase
SCRG1 stimulator of chondrogenesis 1
SFTPC surfactant protein C
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
SQSTM1 sequestosome 1
SSR4 signal sequence receptor, delta
STC2 stanniocalcin 2
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ASRGL1 asparaginase like 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BICC1 BicC family RNA binding protein 1
BPIFA1 BPI fold containing family A, member 1
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHL1 cell adhesion molecule L1-like
CLDN10 claudin 10
COCH cochlin
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DCBLD2 discoidin, CUB and LCCL domain containing 2
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FMO1 flavin containing monooxygenase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
HMGA1 high mobility group AT-hook 1
HOXC6 homeobox C6
HP haptoglobin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF1R insulin-like growth factor 1 receptor
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC16A leucine rich repeat containing 16A
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY75 lymphocyte antigen 75
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K6 mitogen-activated protein kinase kinase 6
MUC4 mucin 4, cell surface associated
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH2 notch 2
NTS neurotensin
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLXNC1 plexin C1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRRC2C proline-rich coiled-coil 2C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA4 RAS p21 protein activator 4
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SET SET nuclear proto-oncogene
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC44A4 solute carrier family 44, member 4
SLIRP SRA stem-loop interacting RNA binding protein
SPRR3 small proline-rich protein 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN8 tetraspanin 8
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican