BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGTR1 angiotensin II receptor, type 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CCND2 cyclin D2
CD14 CD14 molecule
CD163 CD163 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFB complement factor B
CLEC5A C-type lectin domain family 5, member A
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ENO2 enolase 2 (gamma, neuronal)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FLOT1 flotillin 1
FRY furry homolog (Drosophila)
GLUL glutamate-ammonia ligase
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
LIMCH1 LIM and calponin homology domains 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MEF2C myocyte enhancer factor 2C
MKNK1 MAP kinase interacting serine/threonine kinase 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEB nebulin
NGRN neugrin, neurite outgrowth associated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHKA1 phosphorylase kinase, alpha 1 (muscle)
POSTN periostin, osteoblast specific factor
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAB1 stabilin 1
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TBX2 T-box 2
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIRC2 baculoviral IAP repeat containing 2
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHL1 cell adhesion molecule L1-like
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
DLC1 DLC1 Rho GTPase activating protein
DPYSL3 dihydropyrimidinase-like 3
DUSP22 dual specificity phosphatase 22
EGR3 early growth response 3
FBLN1 fibulin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MATN2 matrilin 2
MMD monocyte to macrophage differentiation-associated
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PHACTR2 phosphatase and actin regulator 2
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS11 ribosomal protein S11
SELE selectin E
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TARP TCR gamma alternate reading frame protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNDC9 thioredoxin domain containing 9
VCL vinculin
XIST X inactive specific transcript (non-protein coding)