BRD-K27450477_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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105 genes differentially expressed following the BRD-K27450477_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CD163 CD163 molecule
CD9 CD9 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL3 dihydropyrimidinase-like 3
EPHA2 EPH receptor A2
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INHBB inhibin, beta B
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG1 jagged 1
KRT18 keratin 18, type I
LOXL2 lysyl oxidase-like 2
MEIS2 Meis homeobox 2
MYL9 myosin, light chain 9, regulatory
NR2F1 nuclear receptor subfamily 2, group F, member 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTX3 pentraxin 3, long
RGCC regulator of cell cycle
SCD5 stearoyl-CoA desaturase 5
STAB1 stabilin 1
TGFB1 transforming growth factor, beta 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VSIG4 V-set and immunoglobulin domain containing 4
WT1 Wilms tumor 1

decreased expression

Symbol Name
AGA aspartylglucosaminidase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALG8 ALG8, alpha-1,3-glucosyltransferase
ATAD2 ATPase family, AAA domain containing 2
C3ORF14 chromosome 3 open reading frame 14
CCDC86 coiled-coil domain containing 86
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO2 flavin containing monooxygenase 2 (non-functional)
GPNMB glycoprotein (transmembrane) nmb
HADH hydroxyacyl-CoA dehydrogenase
KIF2C kinesin family member 2C
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RNASE4 ribonuclease, RNase A family, 4
RRM1 ribonucleotide reductase M1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SMC2 structural maintenance of chromosomes 2
SRSF1 serine/arginine-rich splicing factor 1
TFPI2 tissue factor pathway inhibitor 2
TMPO thymopoietin
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
WFDC2 WAP four-disulfide core domain 2
ZWINT ZW10 interacting kinetochore protein