BRD-K27305650_LY-294002_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K27305650_LY-294002_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
ADGRF5 adhesion G protein-coupled receptor F5
ALCAM activated leukocyte cell adhesion molecule
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DENND1B DENN/MADD domain containing 1B
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DUSP4 dual specificity phosphatase 4
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H4J histone cluster 1, H4j
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
PAWR PRKC, apoptosis, WT1, regulator
PRKCI protein kinase C, iota
RFTN1 raftlin, lipid raft linker 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SH3BGRL SH3 domain binding glutamate-rich protein like
SMAD3 SMAD family member 3
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUFT1 tuftelin 1
WEE1 WEE1 G2 checkpoint kinase

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
CCND2 cyclin D2
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DKC1 dyskeratosis congenita 1, dyskerin
DPT dermatopontin
GSPT1 G1 to S phase transition 1
HBB hemoglobin, beta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INPP1 inositol polyphosphate-1-phosphatase
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
NDN necdin, melanoma antigen (MAGE) family member
NEFL neurofilament, light polypeptide
NOLC1 nucleolar and coiled-body phosphoprotein 1
PENK proenkephalin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PPIF peptidylprolyl isomerase F
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SCG5 secretogranin V
SFPQ splicing factor proline/glutamine-rich
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF2 serine/arginine-rich splicing factor 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TNC tenascin C
TRAPPC3 trafficking protein particle complex 3
WDR12 WD repeat domain 12