BRD-K27169919_ethyl {[4-(4-fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl}acetate_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K27169919_ethyl {[4-(4-fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl}acetate_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IL6 interleukin 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
LUM lumican
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RHOB ras homolog family member B
SFN stratifin
SPRR2B small proline-rich protein 2B
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
CADPS2 Ca++-dependent secretion activator 2
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCA4 cell division cycle associated 4
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FABP4 fatty acid binding protein 4, adipocyte
FLRT2 fibronectin leucine rich transmembrane protein 2
GLIPR1 GLI pathogenesis-related 1
GPC4 glypican 4
HHEX hematopoietically expressed homeobox
HLA-DRA major histocompatibility complex, class II, DR alpha
IFI44L interferon-induced protein 44-like
ISOC1 isochorismatase domain containing 1
MAGEA3 melanoma antigen family A3
NFIB nuclear factor I/B
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
TARBP1 TAR (HIV-1) RNA binding protein 1