BRD-K26997899_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K26997899_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADAM9 ADAM metallopeptidase domain 9
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
BIK BCL2-interacting killer (apoptosis-inducing)
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKM creatine kinase, muscle
CPA3 carboxypeptidase A3 (mast cell)
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMXL2 Dmx-like 2
DOCK4 dedicator of cytokinesis 4
DPYSL2 dihydropyrimidinase-like 2
EDN1 endothelin 1
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
HIST1H1C histone cluster 1, H1c
IGFBP7 insulin-like growth factor binding protein 7
INHBB inhibin, beta B
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLHL41 kelch-like family member 41
LDLR low density lipoprotein receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MEG3 maternally expressed 3 (non-protein coding)
MPHOSPH6 M-phase phosphoprotein 6
MPP1 membrane protein, palmitoylated 1, 55kDa
MT1E metallothionein 1E
MYBPC2 myosin binding protein C, fast type
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NEB nebulin
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PAWR PRKC, apoptosis, WT1, regulator
PDLIM3 PDZ and LIM domain 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PHF1 PHD finger protein 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRE protein tyrosine phosphatase, receptor type, E
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RNF130 ring finger protein 130
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERINC5 serine incorporator 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
ST18 suppression of tumorigenicity 18, zinc finger
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCF3 transcription factor 3
TGFA transforming growth factor, alpha
TNNC2 troponin C type 2 (fast)
TNNI2 troponin I type 2 (skeletal, fast)
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBA4A tubulin, alpha 4a
XCL1 chemokine (C motif) ligand 1
YBX3 Y box binding protein 3
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA9 annexin A9
ARMCX3 armadillo repeat containing, X-linked 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CAPN6 calpain 6
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPNE3 copine III
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRTAP cartilage associated protein
CXCL12 chemokine (C-X-C motif) ligand 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FOLR1 folate receptor 1 (adult)
GATA3 GATA binding protein 3
GNPDA1 glucosamine-6-phosphate deaminase 1
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HLF hepatic leukemia factor
HOXA5 homeobox A5
IFITM1 interferon induced transmembrane protein 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIAA0125 KIAA0125
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAN2A1 mannosidase, alpha, class 2A, member 1
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MRPS2 mitochondrial ribosomal protein S2
NAMPT nicotinamide phosphoribosyltransferase
NEFL neurofilament, light polypeptide
OLFM1 olfactomedin 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
RRM2 ribonucleotide reductase M2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMC2 structural maintenance of chromosomes 2
SORD sorbitol dehydrogenase
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN2 stathmin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TPD52L1 tumor protein D52-like 1
TSPAN6 tetraspanin 6
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBL3 ubiquitin-like 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1