BRD-K26818574_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K26818574_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD9 CD9 molecule
COL10A1 collagen, type X, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHCR24 24-dehydrocholesterol reductase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
EBP emopamil binding protein (sterol isomerase)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ENO2 enolase 2 (gamma, neuronal)
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBP1 fructose-1,6-bisphosphatase 1
GOLT1B golgi transport 1B
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NPC1 Niemann-Pick disease, type C1
NPY1R neuropeptide Y receptor Y1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PANK3 pantothenate kinase 3
PLAU plasminogen activator, urokinase
PLSCR1 phospholipid scramblase 1
PSD3 pleckstrin and Sec7 domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RSAD2 radical S-adenosyl methionine domain containing 2
SAMD9 sterile alpha motif domain containing 9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC43A3 solute carrier family 43, member 3
SOAT1 sterol O-acyltransferase 1
SP110 SP110 nuclear body protein
SPINK1 serine peptidase inhibitor, Kazal type 1
ST7 suppression of tumorigenicity 7
STAT1 signal transducer and activator of transcription 1, 91kDa
TMEM97 transmembrane protein 97
TOP1 topoisomerase (DNA) I
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTC1 actin, alpha, cardiac muscle 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASRGL1 asparaginase like 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BIRC5 baculoviral IAP repeat containing 5
CA1 carbonic anhydrase I
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD200 CD200 molecule
CD24 CD24 molecule
CDC42 cell division cycle 42
CFD complement factor D (adipsin)
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
DLK1 delta-like 1 homolog (Drosophila)
ELANE elastase, neutrophil expressed
FBLN5 fibulin 5
FGFR4 fibroblast growth factor receptor 4
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HSPG2 heparan sulfate proteoglycan 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
METRN meteorin, glial cell differentiation regulator
MID1 midline 1
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NME4 NME/NM23 nucleoside diphosphate kinase 4
OSR2 odd-skipped related transciption factor 2
PERP PERP, TP53 apoptosis effector
PFN2 profilin 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
POU4F1 POU class 4 homeobox 1
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RHOB ras homolog family member B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB2A1 secretoglobin, family 2A, member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
TCEA2 transcription elongation factor A (SII), 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM47 transmembrane protein 47
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
WWTR1 WW domain containing transcription regulator 1