BRD-K26669427_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K26669427_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARG2 arginase 2
C10ORF10 chromosome 10 open reading frame 10
CASP10 caspase 10, apoptosis-related cysteine peptidase
CLIC2 chloride intracellular channel 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MDFIC MyoD family inhibitor domain containing
N4BP2L1 NEDD4 binding protein 2-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NXN nucleoredoxin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TDO2 tryptophan 2,3-dioxygenase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
CDC42 cell division cycle 42
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5B eukaryotic translation initiation factor 5B
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYZ lysozyme
MMP9 matrix metallopeptidase 9
MRPL19 mitochondrial ribosomal protein L19
PITX1 paired-like homeodomain 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS3 protease, serine, 3
PTCH1 patched 1
REG1A regenerating islet-derived 1 alpha
RGS4 regulator of G-protein signaling 4
S100P S100 calcium binding protein P
SCG2 secretogranin II
SOX9 SRY (sex determining region Y)-box 9
SRSF6 serine/arginine-rich splicing factor 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)