BRD-K26669427_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K26669427_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTC1 actin, alpha, cardiac muscle 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CPM carboxypeptidase M
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGFR epidermal growth factor receptor
FAM129A family with sequence similarity 129, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GOLM1 golgi membrane protein 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL1R1 interleukin 1 receptor, type I
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LIMCH1 LIM and calponin homology domains 1
LRP12 low density lipoprotein receptor-related protein 12
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
MAPK6 mitogen-activated protein kinase 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRCAM neuronal cell adhesion molecule
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPAP2B phosphatidic acid phosphatase type 2B
RND3 Rho family GTPase 3
RRAGD Ras-related GTP binding D
RYBP RING1 and YY1 binding protein
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
TACSTD2 tumor-associated calcium signal transducer 2
TBL1X transducin (beta)-like 1X-linked
TBPL1 TBP-like 1
TNPO1 transportin 1
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
B3GNT1
CD14 CD14 molecule
CD46 CD46 molecule, complement regulatory protein
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
CXADR coxsackie virus and adenovirus receptor
DHCR24 24-dehydrocholesterol reductase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FAM198B family with sequence similarity 198, member B
FASN fatty acid synthase
FN1 fibronectin 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GMDS GDP-mannose 4,6-dehydratase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LRRN3 leucine rich repeat neuronal 3
OPHN1 oligophrenin 1
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
TF transferrin
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VCAN versican