BRD-K26669427_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K26669427_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AQP1 aquaporin 1 (Colton blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AXIN1 axin 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ELANE elastase, neutrophil expressed
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GCH1 GTP cyclohydrolase 1
HIST1H2BG histone cluster 1, H2bg
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLHL21 kelch-like family member 21
KRT6B keratin 6B, type II
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRD protein tyrosine phosphatase, receptor type, D
RNF19B ring finger protein 19B
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24D SEC24 family member D
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APMAP adipocyte plasma membrane associated protein
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BIRC5 baculoviral IAP repeat containing 5
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25B cell division cycle 25B
DEPTOR DEP domain containing MTOR-interacting protein
ESR1 estrogen receptor 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOPX HOP homeobox
IGFBP3 insulin-like growth factor binding protein 3
IQGAP2 IQ motif containing GTPase activating protein 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MOK MOK protein kinase
NELL2 NEL-like 2 (chicken)
PRSS23 protease, serine, 23
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RUNX3 runt-related transcription factor 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SMYD3 SET and MYND domain containing 3
SRPX sushi-repeat containing protein, X-linked