BRD-K26664453_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K26664453_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADCK3 aarF domain containing kinase 3
AKR1C1 aldo-keto reductase family 1, member C1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C14ORF132 chromosome 14 open reading frame 132
C1S complement component 1, s subcomponent
C2CD2 C2 calcium-dependent domain containing 2
CBS cystathionine-beta-synthase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR1 fibroblast growth factor receptor 1
FKBP11 FK506 binding protein 11, 19 kDa
FOXO4 forkhead box O4
FZD10 frizzled class receptor 10
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUL glutamate-ammonia ligase
GUSBP11 glucuronidase, beta pseudogene 11
HDAC6 histone deacetylase 6
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HYOU1 hypoxia up-regulated 1
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIF14 kinesin family member 14
KLHDC2 kelch domain containing 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MYH11 myosin, heavy chain 11, smooth muscle
NUCB2 nucleobindin 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHIP pleckstrin homology domain interacting protein
PLA2G16 phospholipase A2, group XVI
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC46A3 solute carrier family 46, member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STAR steroidogenic acute regulatory protein
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TST thiosulfate sulfurtransferase (rhodanese)
UGDH UDP-glucose 6-dehydrogenase
VGLL4 vestigial-like family member 4
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WWOX WW domain containing oxidoreductase
XBP1 X-box binding protein 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BYSL bystin-like
BZW1 basic leucine zipper and W2 domains 1
CALD1 caldesmon 1
CCND1 cyclin D1
CCNH cyclin H
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CYR61 cysteine-rich, angiogenic inducer, 61
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EFNB2 ephrin-B2
EGF epidermal growth factor
EHD1 EH-domain containing 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
GMFB glia maturation factor, beta
GTF2A2 general transcription factor IIA, 2, 12kDa
HBEGF heparin-binding EGF-like growth factor
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MOK MOK protein kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTERF3 mitochondrial transcription termination factor 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOP16 NOP16 nucleolar protein
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PAK1IP1 PAK1 interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB27A RAB27A, member RAS oncogene family
RBM12 RNA binding motif protein 12
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TFRC transferrin receptor
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
UBE2N ubiquitin-conjugating enzyme E2N
WBP5 WW domain binding protein 5
ZBED2 zinc finger, BED-type containing 2