BRD-K26664453_-666_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K26664453_-666_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANXA3 annexin A3
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLDN8 claudin 8
COL15A1 collagen, type XV, alpha 1
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA13 heat shock protein 70kDa family, member 13
HSPB8 heat shock 22kDa protein 8
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
LTF lactotransferrin
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MYLK myosin light chain kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PLA2G16 phospholipase A2, group XVI
PLBD1 phospholipase B domain containing 1
PPAP2A phosphatidic acid phosphatase type 2A
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBM47 RNA binding motif protein 47
RGS1 regulator of G-protein signaling 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORBS2 sorbin and SH3 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STAR steroidogenic acute regulatory protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
XBP1 X-box binding protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AHNAK2 AHNAK nucleoprotein 2
ANXA1 annexin A1
C20ORF24 chromosome 20 open reading frame 24
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CDC25B cell division cycle 25B
CLN5 ceroid-lipofuscinosis, neuronal 5
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPX1 glutathione peroxidase 1
HMGB3 high mobility group box 3
HRH1 histamine receptor H1
HSPA1A heat shock 70kDa protein 1A
IER5 immediate early response 5
ISG15 ISG15 ubiquitin-like modifier
ITGB1BP1 integrin beta 1 binding protein 1
LOC100505650 uncharacterized LOC100505650
LYPD1 LY6/PLAUR domain containing 1
MFAP5 microfibrillar associated protein 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
NSG1 neuron specific gene family member 1
NUP62 nucleoporin 62kDa
PAEP progestagen-associated endometrial protein
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PSRC1 proline/serine-rich coiled-coil 1
RHOB ras homolog family member B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SDC1 syndecan 1
SEPW1 selenoprotein W, 1
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXNDC9 thioredoxin domain containing 9
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta