BRD-K26304855_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K26304855_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
AQP9 aquaporin 9
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FLOT1 flotillin 1
FSCN1 fascin actin-bundling protein 1
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HP haptoglobin
HPSE heparanase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KLK8 kallikrein-related peptidase 8
LAPTM4B lysosomal protein transmembrane 4 beta
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
LY96 lymphocyte antigen 96
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MDFIC MyoD family inhibitor domain containing
MMP10 matrix metallopeptidase 10
MUC16 mucin 16, cell surface associated
MYRF myelin regulatory factor
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NSG1 neuron specific gene family member 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RANBP1 RAN binding protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SELENBP1 selenium binding protein 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SKP1 S-phase kinase-associated protein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
TDO2 tryptophan 2,3-dioxygenase
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
UGP2 UDP-glucose pyrophosphorylase 2
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VAMP3 vesicle-associated membrane protein 3
WNT5A wingless-type MMTV integration site family, member 5A
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1C1 aldo-keto reductase family 1, member C1
ARID4B AT rich interactive domain 4B (RBP1-like)
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP350 centrosomal protein 350kDa
CHD1 chromodomain helicase DNA binding protein 1
CHD9 chromodomain helicase DNA binding protein 9
CHSY1 chondroitin sulfate synthase 1
CNOT2 CCR4-NOT transcription complex, subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DND1 DND microRNA-mediated repression inhibitor 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFHD2 EF-hand domain family, member D2
EHD1 EH-domain containing 1
EXOSC4 exosome component 4
FAM222B family with sequence similarity 222, member B
FOXO3 forkhead box O3
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFX H2A histone family, member X
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXC10 homeobox C10
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INSIG1 insulin induced gene 1
INTS5 integrator complex subunit 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR2 lysophosphatidic acid receptor 2
LRIF1 ligand dependent nuclear receptor interacting factor 1
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MGP matrix Gla protein
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NCOA3 nuclear receptor coactivator 3
NFIB nuclear factor I/B
NOTCH2NL notch 2 N-terminal like
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PURA purine-rich element binding protein A
PWP1 PWP1 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RGS5 regulator of G-protein signaling 5
RNF113A ring finger protein 113A
RPP38 ribonuclease P/MRP 38kDa subunit
S100A11 S100 calcium binding protein A11
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SEPHS1 selenophosphate synthetase 1
SEPT6 septin 6
SETD5 SET domain containing 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD1 SMAD family member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYCP2 synaptonemal complex protein 2
TACC2 transforming, acidic coiled-coil containing protein 2
TDG thymine-DNA glycosylase
TESC tescalcin
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THAP11 THAP domain containing 11
TLK2 tousled-like kinase 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WSCD1 WSC domain containing 1
XBP1 X-box binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZIC1 Zic family member 1
ZMYM2 zinc finger, MYM-type 2
ZNF107 zinc finger protein 107
ZNF652 zinc finger protein 652