BRD-K26300881_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K26300881_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CBR3 carbonyl reductase 3
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GAB2 GRB2-associated binding protein 2
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IL1R2 interleukin 1 receptor, type II
KRT18 keratin 18, type I
MAMLD1 mastermind-like domain containing 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
P3H2 prolyl 3-hydroxylase 2
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
S100A7 S100 calcium binding protein A7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TKT transketolase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
APOD apolipoprotein D
ASPN asporin
C8ORF4 chromosome 8 open reading frame 4
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
EIF5A eukaryotic translation initiation factor 5A
FBLN2 fibulin 2
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAM3 junctional adhesion molecule 3
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
NDN necdin, melanoma antigen (MAGE) family member
PELI1 pellino E3 ubiquitin protein ligase 1
POU2AF1 POU class 2 associating factor 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
TFF3 trefoil factor 3 (intestinal)
TIMP1 TIMP metallopeptidase inhibitor 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VCAN versican