BRD-K26241953_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K26241953_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C3 aldo-keto reductase family 1, member C3
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPHL biphenyl hydrolase-like (serine hydrolase)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FST follistatin
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MT1M metallothionein 1M
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
NUAK1 NUAK family, SNF1-like kinase, 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNC1 plexin C1
RGS16 regulator of G-protein signaling 16
RNF13 ring finger protein 13
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SPAG4 sperm associated antigen 4
SPON1 spondin 1, extracellular matrix protein
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TXNRD1 thioredoxin reductase 1
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRL2 adhesion G protein-coupled receptor L2
ANXA3 annexin A3
ARG1 arginase 1
CA1 carbonic anhydrase I
CCNA1 cyclin A1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COCH cochlin
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
FHL1 four and a half LIM domains 1
GPX3 glutathione peroxidase 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MGLL monoglyceride lipase
NEFH neurofilament, heavy polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMT2 N-myristoyltransferase 2
PBX3 pre-B-cell leukemia homeobox 3
PLAC8 placenta-specific 8
SOX11 SRY (sex determining region Y)-box 11
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta