BRD-K26104851_Nifuroxazide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K26104851_Nifuroxazide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ADM adrenomedullin
ANGPTL4 angiopoietin-like 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CAST calpastatin
CBS cystathionine-beta-synthase
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1 eukaryotic translation initiation factor 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETHE1 ethylmalonic encephalopathy 1
F11R F11 receptor
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GDI1 GDP dissociation inhibitor 1
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GPM6A glycoprotein M6A
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GTPBP2 GTP binding protein 2
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
IGL immunoglobulin lambda locus
ITM2C integral membrane protein 2C
KLF5 Kruppel-like factor 5 (intestinal)
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT8 keratin 8, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LYPD3 LY6/PLAUR domain containing 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTSS1 metastasis suppressor 1
MYO1D myosin ID
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
S100A14 S100 calcium binding protein A14
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPB surfactant protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
UBQLN2 ubiquilin 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX2 armadillo repeat containing, X-linked 2
ASCL1 achaete-scute family bHLH transcription factor 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2A1 BCL2-related protein A1
CCL4 chemokine (C-C motif) ligand 4
CCNA2 cyclin A2
CD93 CD93 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CHRDL1 chordin-like 1
CKS2 CDC28 protein kinase regulatory subunit 2
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CPD carboxypeptidase D
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
GSTZ1 glutathione S-transferase zeta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPB8 heat shock 22kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
LAMB1 laminin, beta 1
LCN2 lipocalin 2
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MID1 midline 1
MMP7 matrix metallopeptidase 7
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NKX3-1 NK3 homeobox 1
OLFM4 olfactomedin 4
PALMD palmdelphin
PDZD8 PDZ domain containing 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
STEAP3 STEAP family member 3, metalloreductase
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TMEM100 transmembrane protein 100
TMX4 thioredoxin-related transmembrane protein 4
TNF tumor necrosis factor
TREM1 triggering receptor expressed on myeloid cells 1
TRIM24 tripartite motif containing 24
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZCCHC24 zinc finger, CCHC domain containing 24