BRD-K25737009_-666_MCF7_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K25737009_-666_MCF7_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CGRRF1 cell growth regulator with ring finger domain 1
CLMN calmin (calponin-like, transmembrane)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM208B family with sequence similarity 208, member B
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KRT7 keratin 7, type II
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MOK MOK protein kinase
MSLN mesothelin
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
QKI QKI, KH domain containing, RNA binding
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RND3 Rho family GTPase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC24D SEC24 family member D
SELL selectin L
SERP1 stress-associated endoplasmic reticulum protein 1
SETD5 SET domain containing 5
SFRP4 secreted frizzled-related protein 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SUCO SUN domain containing ossification factor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNGR3 synaptogyrin 3
TAC1 tachykinin, precursor 1
TARS threonyl-tRNA synthetase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX3 T-box 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR2 toll-like receptor 2
TMEM39A transmembrane protein 39A
TMF1 TATA element modulatory factor 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF5 activating transcription factor 5
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1ORF116 chromosome 1 open reading frame 116
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
COCH cochlin
COL4A5 collagen, type IV, alpha 5
CTSV cathepsin V
DDAH1 dimethylarginine dimethylaminohydrolase 1
DPYSL2 dihydropyrimidinase-like 2
EFNB2 ephrin-B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM127A family with sequence similarity 127, member A
FST follistatin
GAL galanin/GMAP prepropeptide
GAS2L1 growth arrest-specific 2 like 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
INSIG1 insulin induced gene 1
JAG2 jagged 2
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYPLA1 lysophospholipase I
MAT2A methionine adenosyltransferase II, alpha
MATN2 matrilin 2
MBOAT2 membrane bound O-acyltransferase domain containing 2
NFIB nuclear factor I/B
NMU neuromedin U
OLFM1 olfactomedin 1
PVALB parvalbumin
RSRP1 arginine/serine-rich protein 1
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
TCF4 transcription factor 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM164 transmembrane protein 164
TMSB15A thymosin beta 15a
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)