BRD-K25662647_FU_JMBII105B_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K25662647_FU_JMBII105B_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AQP1 aquaporin 1 (Colton blood group)
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CTSB cathepsin B
FAM171A1 family with sequence similarity 171, member A1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KIF1B kinesin family member 1B
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KYNU kynureninase
LOX lysyl oxidase
MMP1 matrix metallopeptidase 1
NEO1 neogenin 1
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OXTR oxytocin receptor
PFN2 profilin 2
PGF placental growth factor
PIP prolactin-induced protein
PPAP2B phosphatidic acid phosphatase type 2B
SCG5 secretogranin V
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLPI secretory leukocyte peptidase inhibitor
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TDO2 tryptophan 2,3-dioxygenase
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPP1 tripeptidyl peptidase I
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
C1ORF116 chromosome 1 open reading frame 116
C7 complement component 7
CARD10 caspase recruitment domain family, member 10
CAV1 caveolin 1, caveolae protein, 22kDa
CTSH cathepsin H
CYCS cytochrome c, somatic
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EXT1 exostosin glycosyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXL12 F-box and leucine-rich repeat protein 12
FGFR3 fibroblast growth factor receptor 3
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
JCHAIN joining chain of multimeric IgA and IgM
LIMCH1 LIM and calponin homology domains 1
LRRC59 leucine rich repeat containing 59
MBNL2 muscleblind-like splicing regulator 2
MRPL33 mitochondrial ribosomal protein L33
MYOF myoferlin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PCNA proliferating cell nuclear antigen
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLN phospholamban
PMM2 phosphomannomutase 2
PRNP prion protein
RFC2 replication factor C (activator 1) 2, 40kDa
S100A10 S100 calcium binding protein A10
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK1 serine peptidase inhibitor, Kazal type 1
STK39 serine threonine kinase 39
TFRC transferrin receptor
TNS3 tensin 3
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TUBB2A tubulin, beta 2A class IIa
VAMP8 vesicle-associated membrane protein 8
ZDHHC11 zinc finger, DHHC-type containing 11