BRD-K25536815_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K25536815_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADGRL4 adhesion G protein-coupled receptor L4
ANGPT2 angiopoietin 2
ARID5B AT rich interactive domain 5B (MRF1-like)
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CD93 CD93 molecule
CDK14 cyclin-dependent kinase 14
CFB complement factor B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DEFA5 defensin, alpha 5, Paneth cell-specific
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
ESM1 endothelial cell-specific molecule 1
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDR kinase insert domain receptor
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
NARFL nuclear prelamin A recognition factor-like
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NPTX2 neuronal pentraxin II
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRPA signal-regulatory protein alpha
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMC1A structural maintenance of chromosomes 1A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
SYT1 synaptotagmin I
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM13 tripartite motif containing 13
TRIM2 tripartite motif containing 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHPT1 choline phosphotransferase 1
CIT citron rho-interacting serine/threonine kinase
CLPTM1 cleft lip and palate associated transmembrane protein 1
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EREG epiregulin
EVL Enah/Vasp-like
FOLR1 folate receptor 1 (adult)
GRB14 growth factor receptor-bound protein 14
GTPBP4 GTP binding protein 4
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
NPC2 Niemann-Pick disease, type C2
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PTER phosphotriesterase related
PTGES prostaglandin E synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SCEL sciellin
SET SET nuclear proto-oncogene
SFN stratifin
SIK1 salt-inducible kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFF1 trefoil factor 1
TRAPPC3 trafficking protein particle complex 3
UBE2S ubiquitin-conjugating enzyme E2S
WBSCR22 Williams Beuren syndrome chromosome region 22