BRD-K25433859_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K25433859_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADD3 adducin 3 (gamma)
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
CAB39 calcium binding protein 39
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNB2 ephrin-B2
FASN fatty acid synthase
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FILIP1L filamin A interacting protein 1-like
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NPTX2 neuronal pentraxin II
NSDHL NAD(P) dependent steroid dehydrogenase-like
PRUNE2 prune homolog 2 (Drosophila)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
TIMP1 TIMP metallopeptidase inhibitor 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
BST2 bone marrow stromal cell antigen 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FPGS folylpolyglutamate synthase
HAPLN1 hyaluronan and proteoglycan link protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT7 keratin 7, type II
MAGEA3 melanoma antigen family A3
PLAC8 placenta-specific 8
PODXL podocalyxin-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SMAD7 SMAD family member 7
SRGN serglycin
STAB1 stabilin 1
TOR1A torsin family 1, member A (torsin A)
TUSC3 tumor suppressor candidate 3