BRD-K25433859_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K25433859_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
BEX4 brain expressed, X-linked 4
CAST calpastatin
CCNE2 cyclin E2
CLIC4 chloride intracellular channel 4
CRIP2 cysteine-rich protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
GAGE3 G antigen 3
GREM1 gremlin 1, DAN family BMP antagonist
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
LY75 lymphocyte antigen 75
MAGEA6 melanoma antigen family A6
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PLAU plasminogen activator, urokinase
PLXND1 plexin D1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRR15L proline rich 15-like
PTPRF protein tyrosine phosphatase, receptor type, F
RAD51C RAD51 paralog C
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SMYD3 SET and MYND domain containing 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SRGN serglycin
STC1 stanniocalcin 1
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ANXA3 annexin A3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BZW2 basic leucine zipper and W2 domains 2
CELF2 CUGBP, Elav-like family member 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GLS glutaminase
GPX1 glutathione peroxidase 1
GTPBP8 GTP-binding protein 8 (putative)
HOMER1 homer scaffolding protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IRF1 interferon regulatory factor 1
ITGA6 integrin, alpha 6
LCN2 lipocalin 2
MOCOS molybdenum cofactor sulfurase
NEFH neurofilament, heavy polypeptide
OAZ1 ornithine decarboxylase antizyme 1
PAK1IP1 PAK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDX2 peroxiredoxin 2
PTRF polymerase I and transcript release factor
RNPS1 RNA binding protein S1, serine-rich domain
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
STK17A serine/threonine kinase 17a
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3