BRD-K24496482_SB590885_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K24496482_SB590885_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDCP1 CUB domain containing protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV1 ets variant 1
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPER1 G protein-coupled estrogen receptor 1
H2AFY H2A histone family, member Y
HBEGF heparin-binding EGF-like growth factor
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD12 potassium channel tetramerization domain containing 12
LAMC2 laminin, gamma 2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NES nestin
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PLS1 plastin 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACTA1 actin, alpha 1, skeletal muscle
ADAM12 ADAM metallopeptidase domain 12
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMACR alpha-methylacyl-CoA racemase
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
CD58 CD58 molecule
CELF2 CUGBP, Elav-like family member 2
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
FBLN1 fibulin 1
GAS1 growth arrest-specific 1
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL32 interleukin 32
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KRT13 keratin 13, type I
KRT23 keratin 23, type I
LMOD1 leiomodin 1 (smooth muscle)
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MYO1D myosin ID
NEFH neurofilament, heavy polypeptide
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
PCP4 Purkinje cell protein 4
PDLIM5 PDZ and LIM domain 5
PENK proenkephalin
PPAP2A phosphatidic acid phosphatase type 2A
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RHOB ras homolog family member B
RORA RAR-related orphan receptor A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
STK26 serine/threonine protein kinase 26
TAGLN transgelin
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRIM16 tripartite motif containing 16
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
ZIC1 Zic family member 1