BRD-K24496482_SB590885_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K24496482_SB590885_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRL2 adhesion G protein-coupled receptor L2
AGR2 anterior gradient 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
C3ORF14 chromosome 3 open reading frame 14
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGA2 high mobility group AT-hook 2
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MOXD1 monooxygenase, DBH-like 1
NEBL nebulette
NPAS2 neuronal PAS domain protein 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTX3 pentraxin 3, long
RGS4 regulator of G-protein signaling 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SMS spermine synthase
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
SVIL supervillin
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TUBB2A tubulin, beta 2A class IIa
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADA adenosine deaminase
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
C5 complement component 5
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CD14 CD14 molecule
CFD complement factor D (adipsin)
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL12 chemokine (C-X-C motif) ligand 12
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
F13A1 coagulation factor XIII, A1 polypeptide
FGB fibrinogen beta chain
GIMAP6 GTPase, IMAP family member 6
GPER1 G protein-coupled estrogen receptor 1
HBB hemoglobin, beta
HSPA2 heat shock 70kDa protein 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYLK myosin light chain kinase
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
TAGLN transgelin
VDAC1 voltage-dependent anion channel 1