BRD-K24496482_SB590885_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K24496482_SB590885_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AREG amphiregulin
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDCP1 CUB domain containing protein 1
COL6A2 collagen, type VI, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST6 cystatin E/M
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR2 early growth response 2
EGR3 early growth response 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
ITGA6 integrin, alpha 6
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MREG melanoregulin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
QPCT glutaminyl-peptide cyclotransferase
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSPYL5 TSPY-like 5
UPP1 uridine phosphorylase 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DERA deoxyribose-phosphate aldolase (putative)
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FOLR1 folate receptor 1 (adult)
GAB2 GRB2-associated binding protein 2
GPX3 glutathione peroxidase 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAUS4 HAUS augmin-like complex, subunit 4
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
KRT4 keratin 4, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NFIB nuclear factor I/B
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PIR pirin (iron-binding nuclear protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
THAP11 THAP domain containing 11
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TSC22D3 TSC22 domain family, member 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)