BRD-K24496482_SB590885_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K24496482_SB590885_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ACTA1 actin, alpha 1, skeletal muscle
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA4 annexin A4
ANXA9 annexin A9
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
C14ORF159 chromosome 14 open reading frame 159
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C6ORF62 chromosome 6 open reading frame 62
CCNG2 cyclin G2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTSA cathepsin A
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM63A family with sequence similarity 63, member A
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GBAP1 glucosidase, beta, acid pseudogene 1
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX4 glutathione peroxidase 4
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2BD histone cluster 1, H2bd
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
LAMP2 lysosomal-associated membrane protein 2
LONP2 lon peptidase 2, peroxisomal
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSG1 neuron specific gene family member 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP2 poly(rC) binding protein 2
PEG3 paternally expressed 3
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLP1 proteolipid protein 1
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PYCARD PYD and CARD domain containing
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOB ras homolog family member B
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC35E2B solute carrier family 35, member E2B
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
SRPK2 SRSF protein kinase 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCTN1 tectonic family member 1
THBS2 thrombospondin 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TST thiosulfate sulfurtransferase (rhodanese)
TTC39A tetratricopeptide repeat domain 39A
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WBP1L WW domain binding protein 1-like
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANXA3 annexin A3
CCND1 cyclin D1
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
COL4A2 collagen, type IV, alpha 2
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
ETV4 ets variant 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT1 G1 to S phase transition 1
HMGA1 high mobility group AT-hook 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LIF leukemia inhibitory factor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLXNA1 plexin A1
PODXL podocalyxin-like
PRMT1 protein arginine methyltransferase 1
RFC2 replication factor C (activator 1) 2, 40kDa
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAGP small cell adhesion glycoprotein
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TRAF3 TNF receptor-associated factor 3
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
VEGFA vascular endothelial growth factor A
ZNF185 zinc finger protein 185 (LIM domain)