BRD-K24426149_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K24426149_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
C1QA complement component 1, q subcomponent, A chain
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ESR1 estrogen receptor 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
LCN2 lipocalin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NBPF10 neuroblastoma breakpoint family, member 10
NQO1 NAD(P)H dehydrogenase, quinone 1
OBSL1 obscurin-like 1
PDGFC platelet derived growth factor C
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TARP TCR gamma alternate reading frame protein
TTC3 tetratricopeptide repeat domain 3
TXNRD1 thioredoxin reductase 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AIM1 absent in melanoma 1
BZW2 basic leucine zipper and W2 domains 2
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CPE carboxypeptidase E
FHL1 four and a half LIM domains 1
GSPT2 G1 to S phase transition 2
H3F3B H3 histone, family 3B (H3.3B)
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
IGL immunoglobulin lambda locus
KRT13 keratin 13, type I
LRRC16A leucine rich repeat containing 16A
MET MET proto-oncogene, receptor tyrosine kinase
MTCL1 microtubule crosslinking factor 1
OLFM4 olfactomedin 4
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLN phospholamban
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL39L ribosomal protein L39-like
SCAND1 SCAN domain containing 1
SDC1 syndecan 1
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF6 serine/arginine-rich splicing factor 6
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNS3 tensin 3
TSPAN8 tetraspanin 8