BRD-K24426149_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K24426149_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADAM28 ADAM metallopeptidase domain 28
AKR1C2 aldo-keto reductase family 1, member C2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ATF3 activating transcription factor 3
C3 complement component 3
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELOVL5 ELOVL fatty acid elongase 5
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GRAMD3 GRAM domain containing 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGKV4-1 immunoglobulin kappa variable 4-1
JUN jun proto-oncogene
LXN latexin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RNF167 ring finger protein 167
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TBP TATA box binding protein
TXNL1 thioredoxin-like 1
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG6 adhesion G protein-coupled receptor G6
ANXA3 annexin A3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CHGB chromogranin B
CHRDL1 chordin-like 1
COL1A2 collagen, type I, alpha 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXT1 exostosin glycosyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXL12 F-box and leucine-rich repeat protein 12
FXYD3 FXYD domain containing ion transport regulator 3
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GNAS GNAS complex locus
IFI16 interferon, gamma-inducible protein 16
ISG15 ISG15 ubiquitin-like modifier
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
LGALS4 lectin, galactoside-binding, soluble, 4
LYZ lysozyme
MBNL2 muscleblind-like splicing regulator 2
MKI67 marker of proliferation Ki-67
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRSS2 protease, serine, 2 (trypsin 2)
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RIPK4 receptor-interacting serine-threonine kinase 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTBN1 spectrin, beta, non-erythrocytic 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
VCAN versican
ZNF91 zinc finger protein 91