BRD-K24201553_SB 269970 hydrochloride_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K24201553_SB 269970 hydrochloride_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CD163 CD163 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
EGFL6 EGF-like-domain, multiple 6
GBP1 guanylate binding protein 1, interferon-inducible
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H1C histone cluster 1, H1c
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IVNS1ABP influenza virus NS1A binding protein
LPAR6 lysophosphatidic acid receptor 6
MPZL2 myelin protein zero-like 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEB nebulin
NGRN neugrin, neurite outgrowth associated
NVL nuclear VCP-like
ORC1 origin recognition complex, subunit 1
PBX3 pre-B-cell leukemia homeobox 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPON2 spondin 2, extracellular matrix protein
STON1 stonin 1
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM35 transmembrane protein 35
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA5 annexin A5
APOD apolipoprotein D
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX1 brain expressed, X-linked 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DIO2 deiodinase, iodothyronine, type II
DUSP22 dual specificity phosphatase 22
FAM98A family with sequence similarity 98, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSN gelsolin
HBB hemoglobin, beta
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
RCAN1 regulator of calcineurin 1
RPS27L ribosomal protein S27-like
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STOM stomatin
TBCB tubulin folding cofactor B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TXNDC9 thioredoxin domain containing 9
UGCG UDP-glucose ceramide glucosyltransferase
ZMAT3 zinc finger, matrin-type 3