BRD-K24156250_NCGC00182393-01_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

257 genes differentially expressed following the BRD-K24156250_NCGC00182393-01_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CAST calpastatin
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNPY3 canopy FGF signaling regulator 3
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DST dystonin
EGR1 early growth response 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD7 frizzled class receptor 7
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLRX2 glutaredoxin 2
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
HPN hepsin
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LST1 leukocyte specific transcript 1
LUM lumican
MFAP2 microfibrillar-associated protein 2
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MT1M metallothionein 1M
NEBL nebulette
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOWAHC sosondowah ankyrin repeat domain family member C
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TBX3 T-box 3
TP63 tumor protein p63
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TYMP thymidine phosphorylase
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZC3H15 zinc finger CCCH-type containing 15
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP10A ATPase, class V, type 10A
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
B3GNT1
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CIRBP cold inducible RNA binding protein
CNR1 cannabinoid receptor 1 (brain)
CPNE3 copine III
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CTPS1 CTP synthase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
F2R coagulation factor II (thrombin) receptor
FAM171A1 family with sequence similarity 171, member A1
FAM216A family with sequence similarity 216, member A
FLNB filamin B, beta
FXYD5 FXYD domain containing ion transport regulator 5
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HP haptoglobin
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LY75 lymphocyte antigen 75
MARCKSL1 MARCKS-like 1
MBNL1 muscleblind-like splicing regulator 1
MEIS1 Meis homeobox 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGLL monoglyceride lipase
MGP matrix Gla protein
MYH11 myosin, heavy chain 11, smooth muscle
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
PODXL podocalyxin-like
PTTG1 pituitary tumor-transforming 1
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RPP38 ribonuclease P/MRP 38kDa subunit
RPS26 ribosomal protein S26
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSRP1 arginine/serine-rich protein 1
SEPHS1 selenophosphate synthetase 1
SEPT9 septin 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMX1 thioredoxin-related transmembrane protein 1
TNC tenascin C
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
UBE2G2 ubiquitin-conjugating enzyme E2G 2
WRB tryptophan rich basic protein