BRD-K24132293_piperlongumine (HPLC)_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K24132293_piperlongumine (HPLC)_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BRD2 bromodomain containing 2
CACYBP calcyclin binding protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CLDN3 claudin 3
CNOT4 CCR4-NOT transcription complex, subunit 4
COL6A1 collagen, type VI, alpha 1
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EGR1 early growth response 1
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GEM GTP binding protein overexpressed in skeletal muscle
GMFG glia maturation factor, gamma
H3F3B H3 histone, family 3B (H3.3B)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
JMJD6 jumonji domain containing 6
LAPTM5 lysosomal protein transmembrane 5
MAN1A1 mannosidase, alpha, class 1A, member 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NRIP1 nuclear receptor interacting protein 1
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
PAPOLA poly(A) polymerase alpha
PDLIM5 PDZ and LIM domain 5
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RLF rearranged L-myc fusion
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SOWAHC sosondowah ankyrin repeat domain family member C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
ZFP36 ZFP36 ring finger protein
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACP6 acid phosphatase 6, lysophosphatidic
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CHGB chromogranin B
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
FBN2 fibrillin 2
FST follistatin
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
MCM4 minichromosome maintenance complex component 4
MRPL15 mitochondrial ribosomal protein L15
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NUAK1 NUAK family, SNF1-like kinase, 1
OLFM4 olfactomedin 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
SDC1 syndecan 1
SDC4 syndecan 4
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA1A tubulin, alpha 1a
VCAN versican
XIST X inactive specific transcript (non-protein coding)