BRD-K24132293_PIPLARTINE_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K24132293_PIPLARTINE_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BCHE butyrylcholinesterase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CD163 CD163 molecule
CHMP2A charged multivesicular body protein 2A
CTSV cathepsin V
CYBB cytochrome b-245, beta polypeptide
DCTN1 dynactin 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EGR1 early growth response 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GSN gelsolin
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTA1 metastasis associated 1
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NANS N-acetylneuraminic acid synthase
NGRN neugrin, neurite outgrowth associated
NPEPL1 aminopeptidase-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRD1 nardilysin (N-arginine dibasic convertase)
NT5E 5'-nucleotidase, ecto (CD73)
P4HB prolyl 4-hydroxylase, beta polypeptide
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTCH1 patched 1
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
THBS4 thrombospondin 4
TSPAN8 tetraspanin 8
TWF1 twinfilin actin binding protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
WWOX WW domain containing oxidoreductase

decreased expression

Symbol Name
ALB albumin
APP amyloid beta (A4) precursor protein
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASB13 ankyrin repeat and SOCS box containing 13
ASPA aspartoacylase
ASPH aspartate beta-hydroxylase
ATP13A3 ATPase type 13A3
BAG5 BCL2-associated athanogene 5
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CLDND1 claudin domain containing 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
GSPT2 G1 to S phase transition 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
IER3 immediate early response 3
IL1R1 interleukin 1 receptor, type I
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0907 KIAA0907
KLF9 Kruppel-like factor 9
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
LEPROT leptin receptor overlapping transcript
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL3 methyltransferase like 3
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP153 nucleoporin 153kDa
NXT1 nuclear transport factor 2-like export factor 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PANK3 pantothenate kinase 3
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PKD2 polycystic kidney disease 2 (autosomal dominant)
PTHLH parathyroid hormone-like hormone
PTX3 pentraxin 3, long
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSBN1 round spermatid basic protein 1
RYBP RING1 and YY1 binding protein
SDC4 syndecan 4
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPP1 selenoprotein P, plasma, 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMAD1 SMAD family member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPTSSA serine palmitoyltransferase, small subunit A
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMF1 TATA element modulatory factor 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
ZBTB18 zinc finger and BTB domain containing 18
ZNF217 zinc finger protein 217
ZNF589 zinc finger protein 589