BRD-K24132293_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K24132293_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCHE butyrylcholinesterase
BZW2 basic leucine zipper and W2 domains 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNL1 cyclin L1
CENPU centromere protein U
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IL18 interleukin 18
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
NDRG1 N-myc downstream regulated 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLTP phospholipid transfer protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SORBS1 sorbin and SH3 domain containing 1
SYT1 synaptotagmin I
TDO2 tryptophan 2,3-dioxygenase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM255A transmembrane protein 255A
TXNL4B thioredoxin-like 4B
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
B3GNT1
CA12 carbonic anhydrase XII
CD58 CD58 molecule
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DENND2D DENN/MADD domain containing 2D
EPCAM epithelial cell adhesion molecule
GATA3 GATA binding protein 3
HES1 hes family bHLH transcription factor 1
IGF1R insulin-like growth factor 1 receptor
KCTD12 potassium channel tetramerization domain containing 12
KIAA0391 KIAA0391
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MBP myelin basic protein
MED28 mediator complex subunit 28
MGP matrix Gla protein
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
PRKCH protein kinase C, eta
RBM47 RNA binding motif protein 47
RPS27L ribosomal protein S27-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TMEM30B transmembrane protein 30B
VCAN versican