BRD-K24051260_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K24051260_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AKAP12 A kinase (PRKA) anchor protein 12
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CALR calreticulin
COL1A1 collagen, type I, alpha 1
CRIP2 cysteine-rich protein 2
CTSZ cathepsin Z
DEFA5 defensin, alpha 5, Paneth cell-specific
DLK1 delta-like 1 homolog (Drosophila)
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FGL2 fibrinogen-like 2
FST follistatin
GAL galanin/GMAP prepropeptide
HEPH hephaestin
HOMER3 homer scaffolding protein 3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IL1R2 interleukin 1 receptor, type II
JAG1 jagged 1
LGALS4 lectin, galactoside-binding, soluble, 4
LOC100286895 cell division cycle 27 homolog pseudogene
MAOA monoamine oxidase A
MMP11 matrix metallopeptidase 11
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCAM1 neural cell adhesion molecule 1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PROCR protein C receptor, endothelial
PRTN3 proteinase 3
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPINK4 serine peptidase inhibitor, Kazal type 4
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
ZBTB18 zinc finger and BTB domain containing 18
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ABI1 abl-interactor 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY1 adenylate cyclase 1 (brain)
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMOTL2 angiomotin like 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX2 armadillo repeat containing, X-linked 2
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CCNB2 cyclin B2
CD24 CD24 molecule
CDK4 cyclin-dependent kinase 4
CHMP4A charged multivesicular body protein 4A
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EIF5A eukaryotic translation initiation factor 5A
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KYNU kynureninase
LACTB2 lactamase, beta 2
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MOAP1 modulator of apoptosis 1
MYH10 myosin, heavy chain 10, non-muscle
MYO5C myosin VC
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV2 neuron navigator 2
NCK2 NCK adaptor protein 2
NEBL nebulette
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRDX1 peroxiredoxin 1
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RABGAP1 RAB GTPase activating protein 1
RBBP8 retinoblastoma binding protein 8
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REEP5 receptor accessory protein 5
RFK riboflavin kinase
RNF6 ring finger protein (C3H2C3 type) 6
S100A13 S100 calcium binding protein A13
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOAT1 sterol O-acyltransferase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STS steroid sulfatase (microsomal), isozyme S
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM29 tripartite motif containing 29
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TSPYL4 TSPY-like 4
TSPYL5 TSPY-like 5
UBE3C ubiquitin protein ligase E3C
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPO7 exportin 7
ZEB2 zinc finger E-box binding homeobox 2
ZNF185 zinc finger protein 185 (LIM domain)