BRD-K24051260_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K24051260_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
CRP C-reactive protein, pentraxin-related
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM7A lysine (K)-specific demethylase 7A
KIAA0226L KIAA0226-like
LOX lysyl oxidase
LY96 lymphocyte antigen 96
MME membrane metallo-endopeptidase
MPZL2 myelin protein zero-like 2
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1M metallothionein 1M
NT5E 5'-nucleotidase, ecto (CD73)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RNF24 ring finger protein 24
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
TCF4 transcription factor 4
TMEM45A transmembrane protein 45A
TNS1 tensin 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BASP1 brain abundant, membrane attached signal protein 1
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFNB2 ephrin-B2
FBXO11 F-box protein 11
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GOLGA8A golgin A8 family, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKC immunoglobulin kappa constant
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MPHOSPH9 M-phase phosphoprotein 9
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG3A regenerating islet-derived 3 alpha
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPDEF SAM pointed domain containing ETS transcription factor
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TOB1 transducer of ERBB2, 1