BRD-K24051260_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K24051260_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BMP4 bone morphogenetic protein 4
CD52 CD52 molecule
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DIXDC1 DIX domain containing 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HOXC10 homeobox C10
JCHAIN joining chain of multimeric IgA and IgM
KRT20 keratin 20, type I
LUM lumican
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM4 olfactomedin 4
PERP PERP, TP53 apoptosis effector
POSTN periostin, osteoblast specific factor
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCAN2 regulator of calcineurin 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOCS2 suppressor of cytokine signaling 2
SPINK4 serine peptidase inhibitor, Kazal type 4
SPON1 spondin 1, extracellular matrix protein
STMN2 stathmin 2
TBX3 T-box 3
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
WFDC1 WAP four-disulfide core domain 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
CAB39 calcium binding protein 39
DEFB1 defensin, beta 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GOLM1 golgi membrane protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KIF14 kinesin family member 14
MSX1 msh homeobox 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RBMS1 RNA binding motif, single stranded interacting protein 1
S100A2 S100 calcium binding protein A2
SLPI secretory leukocyte peptidase inhibitor
THBD thrombomodulin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2