BRD-K23922020_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K23922020_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
APOD apolipoprotein D
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BHLHE41 basic helix-loop-helix family, member e41
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD8A CD8a molecule
CSTA cystatin A (stefin A)
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EVI2B ecotropic viral integration site 2B
FAS Fas cell surface death receptor
FXR1 fragile X mental retardation, autosomal homolog 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GSN gelsolin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
IFI27 interferon, alpha-inducible protein 27
ISLR immunoglobulin superfamily containing leucine-rich repeat
MICB MHC class I polypeptide-related sequence B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PSD3 pleckstrin and Sec7 domain containing 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SKAP1 src kinase associated phosphoprotein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRBC1 T cell receptor beta constant 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AQP1 aquaporin 1 (Colton blood group)
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CLU clusterin
CYB5A cytochrome b5 type A (microsomal)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNTT DNA nucleotidylexotransferase
EIF5A eukaryotic translation initiation factor 5A
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
HHEX hematopoietically expressed homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LOX lysyl oxidase
MAT2A methionine adenosyltransferase II, alpha
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MTCL1 microtubule crosslinking factor 1
PTX3 pentraxin 3, long
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TCF4 transcription factor 4
TXNDC9 thioredoxin domain containing 9
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586