BRD-K23582869_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K23582869_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
AKAP12 A kinase (PRKA) anchor protein 12
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AOX1 aldehyde oxidase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CD200 CD200 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRABP2 cellular retinoic acid binding protein 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
FADS1 fatty acid desaturase 1
FCGBP Fc fragment of IgG binding protein
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPX3 glutathione peroxidase 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IDS iduronate 2-sulfatase
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITFG1 integrin alpha FG-GAP repeat containing 1
IVNS1ABP influenza virus NS1A binding protein
KLF2 Kruppel-like factor 2
LDLR low density lipoprotein receptor
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MTA1 metastasis associated 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH11 myosin, heavy chain 11, smooth muscle
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NOTCH3 notch 3
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAT plasminogen activator, tissue
PRKCI protein kinase C, iota
RAB29 RAB29, member RAS oncogene family
RAB33A RAB33A, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
RHOQ ras homolog family member Q
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TRAK2 trafficking protein, kinesin binding 2
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
AUTS2 autism susceptibility candidate 2
CD9 CD9 molecule
CHI3L2 chitinase 3-like 2
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
CTSC cathepsin C
CTSG cathepsin G
DACH1 dachshund family transcription factor 1
DLK1 delta-like 1 homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HEBP2 heme binding protein 2
HOXA5 homeobox A5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCTD12 potassium channel tetramerization domain containing 12
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MMP7 matrix metallopeptidase 7
MTCL1 microtubule crosslinking factor 1
NDN necdin, melanoma antigen (MAGE) family member
NEBL nebulette
NPAS2 neuronal PAS domain protein 2
NPY neuropeptide Y
PDLIM1 PDZ and LIM domain 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL39L ribosomal protein L39-like
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPC surfactant protein C
SLC44A4 solute carrier family 44, member 4
SLPI secretory leukocyte peptidase inhibitor
SOCS2 suppressor of cytokine signaling 2
SPAG6 sperm associated antigen 6
STAB1 stabilin 1
TARP TCR gamma alternate reading frame protein
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VNN1 vanin 1