BRD-K23478508_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K23478508_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADM adrenomedullin
ANXA3 annexin A3
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CCNL1 cyclin L1
CD36 CD36 molecule (thrombospondin receptor)
CDK17 cyclin-dependent kinase 17
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CGA glycoprotein hormones, alpha polypeptide
CHERP calcium homeostasis endoplasmic reticulum protein
CLIC5 chloride intracellular channel 5
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EIF1 eukaryotic translation initiation factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FAM60A family with sequence similarity 60, member A
FGF13 fibroblast growth factor 13
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
NCOA2 nuclear receptor coactivator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
NXN nucleoredoxin
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOB ras homolog family member B
SASH1 SAM and SH3 domain containing 1
SC5D sterol-C5-desaturase
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
STC1 stanniocalcin 1
STOM stomatin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
WEE1 WEE1 G2 checkpoint kinase
ZBED2 zinc finger, BED-type containing 2
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ACTN1 actinin, alpha 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA6 annexin A6
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
B3GNT1
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CD44 CD44 molecule (Indian blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
COG2 component of oligomeric golgi complex 2
CP ceruloplasmin (ferroxidase)
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF5 eukaryotic translation initiation factor 5
FAM107A family with sequence similarity 107, member A
FBXO9 F-box protein 9
FCGBP Fc fragment of IgG binding protein
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INTS3 integrator complex subunit 3
MAT2A methionine adenosyltransferase II, alpha
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSLN mesothelin
MSMB microseminoprotein, beta-
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
OXA1L oxidase (cytochrome c) assembly 1-like
PCYOX1L prenylcysteine oxidase 1 like
PFKP phosphofructokinase, platelet
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTN pleiotrophin
PWP1 PWP1 homolog (S. cerevisiae)
RAP2A RAP2A, member of RAS oncogene family
RNASET2 ribonuclease T2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SRSF6 serine/arginine-rich splicing factor 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THYN1 thymocyte nuclear protein 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMCO6 transmembrane and coiled-coil domains 6
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XBP1 X-box binding protein 1
ZNF32 zinc finger protein 32