BRD-K23478508_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

387 genes differentially expressed following the BRD-K23478508_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACP5 acid phosphatase 5, tartrate resistant
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD12 ankyrin repeat domain 12
AQP3 aquaporin 3 (Gill blood group)
ARL8B ADP-ribosylation factor-like 8B
ATAD2 ATPase family, AAA domain containing 2
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZU1 azurocidin 1
BAMBI BMP and activin membrane-bound inhibitor
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNH cyclin H
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CFAP20 cilia and flagella associated protein 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTA cystatin A (stefin A)
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DUSP14 dual specificity phosphatase 14
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FNDC3B fibronectin type III domain containing 3B
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
GTF2B general transcription factor IIB
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM6A lysine (K)-specific demethylase 6A
KDM7A lysine (K)-specific demethylase 7A
KIDINS220 kinase D-interacting substrate, 220kDa
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLK5 kallikrein-related peptidase 5
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KYNU kynureninase
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
M6PR mannose-6-phosphate receptor (cation dependent)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MCTP1 multiple C2 domains, transmembrane 1
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MTF2 metal response element binding transcription factor 2
NCK1 NCK adaptor protein 1
NEU1 sialidase 1 (lysosomal sialidase)
NUPL1 nucleoporin like 1
OLFML2A olfactomedin-like 2A
OSTM1 osteopetrosis associated transmembrane protein 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PER2 period circadian clock 2
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRRC2C proline-rich coiled-coil 2C
PSPC1 paraspeckle component 1
PTTG1 pituitary tumor-transforming 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAD21 RAD21 homolog (S. pombe)
RAE1 ribonucleic acid export 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS5 regulator of G-protein signaling 5
RLF rearranged L-myc fusion
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SDCBP syndecan binding protein (syntenin)
SEC62 SEC62 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SGPP1 sphingosine-1-phosphate phosphatase 1
SIK3 SIK family kinase 3
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRSF10 serine/arginine-rich splicing factor 10
SRSF7 serine/arginine-rich splicing factor 7
STX3 syntaxin 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYPL1 synaptophysin-like 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TMEM30B transmembrane protein 30B
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TXNL4B thioredoxin-like 4B
UBE2C ubiquitin-conjugating enzyme E2C
UFM1 ubiquitin-fold modifier 1
UQCRH ubiquinol-cytochrome c reductase hinge protein
USP15 ubiquitin specific peptidase 15
XIST X inactive specific transcript (non-protein coding)
ZC3H13 zinc finger CCCH-type containing 13
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
ZNF165 zinc finger protein 165
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD2 abhydrolase domain containing 2
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ADD1 adducin 1 (alpha)
ADSL adenylosuccinate lyase
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ANXA6 annexin A6
ARHGAP1 Rho GTPase activating protein 1
ASL argininosuccinate lyase
ASMTL acetylserotonin O-methyltransferase-like
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BICC1 BicC family RNA binding protein 1
BIN1 bridging integrator 1
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTN3A2 butyrophilin, subfamily 3, member A2
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
CADPS2 Ca++-dependent secretion activator 2
CAPN2 calpain 2, (m/II) large subunit
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCNI cyclin I
CD151 CD151 molecule (Raph blood group)
CDC16 cell division cycle 16
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CETN2 centrin, EF-hand protein, 2
CHL1 cell adhesion molecule L1-like
CHRDL1 chordin-like 1
COL6A1 collagen, type VI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPNE3 copine III
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
CTBP1 C-terminal binding protein 1
CYB5A cytochrome b5 type A (microsomal)
DCPS decapping enzyme, scavenger
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNASE1L1 deoxyribonuclease I-like 1
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EHD3 EH-domain containing 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENDOD1 endonuclease domain containing 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM114A1 family with sequence similarity 114, member A1
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FASN fatty acid synthase
FDPS farnesyl diphosphate synthase
FLNA filamin A, alpha
FLOT2 flotillin 2
G6PD glucose-6-phosphate dehydrogenase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GAS1 growth arrest-specific 1
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPI glucose-6-phosphate isomerase
GRSF1 G-rich RNA sequence binding factor 1
GSN gelsolin
GTF3A general transcription factor IIIA
GYS1 glycogen synthase 1 (muscle)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ILK integrin-linked kinase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0100 KIAA0100
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP3 latent transforming growth factor beta binding protein 3
LYPLA1 lysophospholipase I
MACF1 microtubule-actin crosslinking factor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MAP1B microtubule-associated protein 1B
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MGLL monoglyceride lipase
MGP matrix Gla protein
MSMB microseminoprotein, beta-
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NES nestin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNMT nicotinamide N-methyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR2F6 nuclear receptor subfamily 2, group F, member 6
NREP neuronal regeneration related protein
OBSL1 obscurin-like 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAM peptidylglycine alpha-amidating monooxygenase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PGLS 6-phosphogluconolactonase
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PKN1 protein kinase N1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PLCL1 phospholipase C-like 1
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRDX4 peroxiredoxin 4
PRKCA protein kinase C, alpha
PRKCDBP protein kinase C, delta binding protein
PRKD1 protein kinase D1
PRUNE2 prune homolog 2 (Drosophila)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
PYGL phosphorylase, glycogen, liver
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
RRAS related RAS viral (r-ras) oncogene homolog
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCO2 SCO2 cytochrome c oxidase assembly protein
SCRG1 stimulator of chondrogenesis 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFXN3 sideroflexin 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMS spermine synthase
SMYD2 SET and MYND domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
STK39 serine threonine kinase 39
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TBCB tubulin folding cofactor B
TBL1X transducin (beta)-like 1X-linked
THBS2 thrombospondin 2
THYN1 thymocyte nuclear protein 1
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM204 transmembrane protein 204
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TRIOBP TRIO and F-actin binding protein
TSC2 tuberous sclerosis 2
TSPAN8 tetraspanin 8
TTC37 tetratricopeptide repeat domain 37
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TWF2 twinfilin actin binding protein 2
TYK2 tyrosine kinase 2
UBL4A ubiquitin-like 4A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
USP34 ubiquitin specific peptidase 34
USP9Y ubiquitin specific peptidase 9, Y-linked
VCAN versican
VKORC1 vitamin K epoxide reductase complex, subunit 1
WNT5A wingless-type MMTV integration site family, member 5A
ZCCHC24 zinc finger, CCHC domain containing 24
ZIC1 Zic family member 1