BRD-K23478508_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K23478508_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
ALDOB aldolase B, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZU1 azurocidin 1
BLNK B-cell linker
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM60A family with sequence similarity 60, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GMFB glia maturation factor, beta
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER2 immediate early response 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL6 interleukin 6
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MGAM maltase-glucoamylase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1G metallothionein 1G
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PENK proenkephalin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SGK1 serum/glucocorticoid regulated kinase 1
STOM stomatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPBG trophoblast glycoprotein
TPM4 tropomyosin 4
UGCG UDP-glucose ceramide glucosyltransferase
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
AQP3 aquaporin 3 (Gill blood group)
ATMIN ATM interactor
C11ORF71 chromosome 11 open reading frame 71
C2ORF68 chromosome 2 open reading frame 68
C3 complement component 3
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNF cyclin F
CD9 CD9 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL1A2 collagen, type I, alpha 2
CRISP3 cysteine-rich secretory protein 3
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FHOD3 formin homology 2 domain containing 3
G6PD glucose-6-phosphate dehydrogenase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GNLY granulysin
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KEAP1 kelch-like ECH-associated protein 1
LIMCH1 LIM and calponin homology domains 1
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MKKS McKusick-Kaufman syndrome
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBEA neurobeachin
NCALD neurocalcin delta
NDRG3 NDRG family member 3
NLRP2 NLR family, pyrin domain containing 2
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
PIP prolactin-induced protein
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIN2 Ras and Rab interactor 2
RNF167 ring finger protein 167
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
SPTSSA serine palmitoyltransferase, small subunit A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNM synemin, intermediate filament protein
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCTA T-cell leukemia translocation altered
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A