BRD-K23282736_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K23282736_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
APOC1 apolipoprotein C-I
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPB1 carboxypeptidase B1 (tissue)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
DCN decorin
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP1 dual specificity phosphatase 1
EPHA4 EPH receptor A4
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
IER3 immediate early response 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MAP2K5 mitogen-activated protein kinase kinase 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
NTS neurotensin
OLFM1 olfactomedin 1
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PNPLA4 patatin-like phospholipase domain containing 4
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPARD peroxisome proliferator-activated receptor delta
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
RTN2 reticulon 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNGR3 synaptogyrin 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AK4 adenylate kinase 4
AKAP1 A kinase (PRKA) anchor protein 1
BPTF bromodomain PHD finger transcription factor
CCND1 cyclin D1
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CXCL13 chemokine (C-X-C motif) ligand 13
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
FAM3C family with sequence similarity 3, member C
FNDC3B fibronectin type III domain containing 3B
HOMER3 homer scaffolding protein 3
IL6R interleukin 6 receptor
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LPCAT1 lysophosphatidylcholine acyltransferase 1
MBP myelin basic protein
MFAP5 microfibrillar associated protein 5
MLEC malectin
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFA platelet-derived growth factor alpha polypeptide
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PTHLH parathyroid hormone-like hormone
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SNX7 sorting nexin 7
SPATS2L spermatogenesis associated, serine-rich 2-like
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TKTL1 transketolase-like 1
TOX thymocyte selection-associated high mobility group box
TUBB2A tubulin, beta 2A class IIa
VGLL1 vestigial-like family member 1
WSB1 WD repeat and SOCS box containing 1