BRD-K23217072_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K23217072_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
CD24 CD24 molecule
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
CSNK1A1 casein kinase 1, alpha 1
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
E2F5 E2F transcription factor 5, p130-binding
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXG1 forkhead box G1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL9 myosin, light chain 9, regulatory
NAV2 neuron navigator 2
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAWR PRKC, apoptosis, WT1, regulator
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPOX protoporphyrinogen oxidase
PTRF polymerase I and transcript release factor
PVALB parvalbumin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
SCG5 secretogranin V
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNX7 sorting nexin 7
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBA1A tubulin, alpha 1a
UPP1 uridine phosphorylase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
C1S complement component 1, s subcomponent
CCNF cyclin F
CDKN3 cyclin-dependent kinase inhibitor 3
CHL1 cell adhesion molecule L1-like
CLIC5 chloride intracellular channel 5
CPVL carboxypeptidase, vitellogenic-like
DCN decorin
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F5 coagulation factor V (proaccelerin, labile factor)
FAM178A family with sequence similarity 178, member A
FAM65B family with sequence similarity 65, member B
FANCI Fanconi anemia, complementation group I
FASTKD5 FAST kinase domains 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPER1 G protein-coupled estrogen receptor 1
GTSE1 G-2 and S-phase expressed 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFI44 interferon-induced protein 44
IL17RB interleukin 17 receptor B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
LONP2 lon peptidase 2, peroxisomal
LPPR1 lipid phosphate phosphatase-related protein type 1
MAGED1 melanoma antigen family D1
METTL3 methyltransferase like 3
MSH6 mutS homolog 6
N4BP2L2 NEDD4 binding protein 2-like 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4B pre-mRNA processing factor 4B
PTTG1 pituitary tumor-transforming 1
RPA2 replication protein A2, 32kDa
RXRA retinoid X receptor, alpha
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TPX2 TPX2, microtubule-associated
USP34 ubiquitin specific peptidase 34
VCAN versican
ZIC1 Zic family member 1