BRD-K22832646_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K22832646_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ANKRD11 ankyrin repeat domain 11
AOX1 aldehyde oxidase 1
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASCL1 achaete-scute family bHLH transcription factor 1
BAG5 BCL2-associated athanogene 5
BCL6 B-cell CLL/lymphoma 6
CCL8 chemokine (C-C motif) ligand 8
CD59 CD59 molecule, complement regulatory protein
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLTC clathrin, heavy chain (Hc)
COPS7A COP9 signalosome subunit 7A
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
ESR1 estrogen receptor 1
FOXJ3 forkhead box J3
GANAB glucosidase, alpha; neutral AB
GATA3 GATA binding protein 3
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HECA headcase homolog (Drosophila)
HIST1H2BD histone cluster 1, H2bd
IDO1 indoleamine 2,3-dioxygenase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLF13 Kruppel-like factor 13
KNG1 kininogen 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MICB MHC class I polypeptide-related sequence B
MTA1 metastasis associated 1
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PDZD2 PDZ domain containing 2
PLSCR3 phospholipid scramblase 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL podocalyxin-like
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKX protein kinase, X-linked
PTCH1 patched 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIOK3 RIO kinase 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSL1D1 ribosomal L1 domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TGFBR3 transforming growth factor, beta receptor III
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TNS3 tensin 3
TOP1 topoisomerase (DNA) I
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ASXL2 additional sex combs like transcriptional regulator 2
AUTS2 autism susceptibility candidate 2
CBR3 carbonyl reductase 3
CD1C CD1c molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEP68 centrosomal protein 68kDa
CHN2 chimerin 2
COLEC12 collectin sub-family member 12
CTSC cathepsin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATAD1 GATA zinc finger domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GTPBP8 GTP-binding protein 8 (putative)
HIST1H4C histone cluster 1, H4c
IER3 immediate early response 3
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INTS3 integrator complex subunit 3
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
LGALS2 lectin, galactoside-binding, soluble, 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MEIS2 Meis homeobox 2
MX1 MX dynamin-like GTPase 1
NDN necdin, melanoma antigen (MAGE) family member
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP1 RAN binding protein 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS1 regulator of G-protein signaling 1
RPL38 ribosomal protein L38
RTN1 reticulon 1
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOAT1 sterol O-acyltransferase 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TMEM97 transmembrane protein 97
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
UGCG UDP-glucose ceramide glucosyltransferase
WSB1 WD repeat and SOCS box containing 1
ZBTB20 zinc finger and BTB domain containing 20