BRD-K22503835_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

452 genes differentially expressed following the BRD-K22503835_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAA1 acetyl-CoA acyltransferase 1
ACLY ATP citrate lyase
ADA adenosine deaminase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG2 BTG family, member 2
C18ORF8 chromosome 18 open reading frame 8
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CALCOCO2 calcium binding and coiled-coil domain 2
CAV2 caveolin 2
CCNG2 cyclin G2
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5 cyclin-dependent kinase 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHGB chromogranin B
CHI3L2 chitinase 3-like 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CORO1C coronin, actin binding protein, 1C
CPVL carboxypeptidase, vitellogenic-like
CYB5A cytochrome b5 type A (microsomal)
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDR2 discoidin domain receptor tyrosine kinase 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMXL2 Dmx-like 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
EVI2A ecotropic viral integration site 2A
EZR ezrin
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FBXO2 F-box protein 2
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD2 FXYD domain containing ion transport regulator 2
FXYD6 FXYD domain containing ion transport regulator 6
GABARAPL2 GABA(A) receptor-associated protein-like 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNS glucosamine (N-acetyl)-6-sulfatase
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IL11RA interleukin 11 receptor, alpha
IL13RA2 interleukin 13 receptor, alpha 2
IL32 interleukin 32
INSIG1 insulin induced gene 1
INSR insulin receptor
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIDINS220 kinase D-interacting substrate, 220kDa
KIF1A kinesin family member 1A
L1CAM L1 cell adhesion molecule
LBH limb bud and heart development
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LPXN leupaxin
MAGEB2 melanoma antigen family B2
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOB monoamine oxidase B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MFAP2 microfibrillar-associated protein 2
MGST3 microsomal glutathione S-transferase 3
MIR22HG MIR22 host gene
MPP1 membrane protein, palmitoylated 1, 55kDa
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NARF nuclear prelamin A recognition factor
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NME7 NME/NM23 family member 7
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPTX2 neuronal pentraxin II
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAIP2B poly(A) binding protein interacting protein 2B
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PRSS3 protease, serine, 3
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB29 RAB29, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
REEP1 receptor accessory protein 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
RRAS related RAS viral (r-ras) oncogene homolog
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SERINC3 serine incorporator 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPC surfactant protein C
SFXN3 sideroflexin 3
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SKAP2 src kinase associated phosphoprotein 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMYD3 SET and MYND domain containing 3
SOX2 SRY (sex determining region Y)-box 2
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
SST somatostatin
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STX1A syntaxin 1A (brain)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCEAL2 transcription elongation factor A (SII)-like 2
TCF21 transcription factor 21
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP2 TIMP metallopeptidase inhibitor 2
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TRIM2 tripartite motif containing 2
TSPAN3 tetraspanin 3
TUBA4A tubulin, alpha 4a
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWC3 WWC family member 3
WWTR1 WW domain containing transcription regulator 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDT1 chromatin licensing and DNA replication factor 1
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKAP4 cytoskeleton-associated protein 4
CTPS2 CTP synthase 2
CYB561 cytochrome b561
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPDC1 DEP domain containing 1
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
ESRP2 epithelial splicing regulatory protein 2
EXOSC8 exosome component 8
F12 coagulation factor XII (Hageman factor)
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FOXM1 forkhead box M1
FXN frataxin
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLUD1 glutamate dehydrogenase 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HDDC2 HD domain containing 2
HDGF hepatoma-derived growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOXB2 homeobox B2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLK10 kallikrein-related peptidase 10
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LIMS1 LIM and senescent cell antigen-like domains 1
LMNB1 lamin B1
LMNB2 lamin B2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MARC1 mitochondrial amidoxime reducing component 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
METTL1 methyltransferase like 1
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MSMB microseminoprotein, beta-
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHP2 NHP2 ribonucleoprotein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRC1 protein regulator of cytokinesis 1
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PTX3 pentraxin 3, long
RAB25 RAB25, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SENP6 SUMO1/sentrin specific peptidase 6
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYPL1 synaptophysin-like 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIM22 tripartite motif containing 22
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TTC39A tetratricopeptide repeat domain 39A
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGDH UDP-glucose 6-dehydrogenase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZWINT ZW10 interacting kinetochore protein